Mammoth BioSciences

OPPORTUNITY Mammoth Biosciences is seeking a highly motivated Scientist II or Senior Scientist I to join our CMC team in a hands-on, cross-functional role that blends scientific ingenuity with operational excellence. This position is critical for developing, optimizing, scaling, and characterizing LNP-based delivery production processes for Mammoth's cutting-edge gene editing platforms. The ideal candidate will thrive at the interface of process development, analytics, and manufacturingsomeone who can transition smoothly between the bench and discussions with external partners. This is a great opportunity to play a key role in advancing transformative gene editing therapies into the clinic and beyond. KEY RESPONSIBILITIES

Design and optimize LNP manufacturing processes by applying Quality by Design (QbD) principles and execute Design of Experiments (DoEs) to identify and control critical process parameters (CPPs)
Optimize analytical methods such as DLS, Ribogreen, HPLC-CAD, IP-RP-HPLC, and endotoxin to identify and access critical quality attributes (CQAs)
Interpret analytical data to assess process robustness and guide iterative development efforts
Collaborate with internal teams to support process improvements and drive innovation
Clearly present scientific findings and project updates in internal meetings and to external collaborators
Drive technology transfer activities with external CDMO partners by preparing comprehensive technical documentation such as development reports, process summaries, and tech transfer packages to ensure successful external manufacturing
Stay current with emerging trends in LNP technologies and contribute to strategic process improvements
Track inventory, plan experiments, and contribute to an organized, quality-focused lab environment

REQUIRED QUALIFICATIONS

Ph.D. in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, or a related field with minimum of 3 years relevant industry experience; or M.S. with 6 years; or B.S. with 8 years
Demonstrated expertise in LNP formulation and process development, including hands-on experience with microfluidic and high-shear mixing technologies, tangential flow filtration and dead-end filtration
Proficiency in analytical characterization techniques for LNPs, including DLS, fluorescence-based assays and HPLC/UPLC methods (CAD, UV, IP-RP, SEC, IEX), including method development, troubleshooting, and data interpretation
Experience with in-process and drug product stability studies
Proven success in applying DoEs and statistical analysis tools for process optimization
Experience supporting technology transfer of processes to external manufacturing environments, with a strong understanding of tech transfer best practices
Demonstrated strong organizational skills
A self-starter with demonstrated strong troubleshooting skills, capable of driving projects independently while contributing effectively in a collaborative, multidisciplinary environment

PREFERRED QUALIFICATIONS

Knowledge of regulatory expectations for CMC development
Familiarity with high-throughput screening methods
Exposure to cell-based assays for LNP functional characterization
Familiarity with data analysis tools and statistical methods such as JMP
Experience with AAV vector process development or a strong interest and adaptability to learn viral delivery systems

BENEFITS

Company-paid health/vision/dental benefits
Unlimited vacation and generous sick time
Company-sponsored meals and snacks
Wellness, caregiver and ergonomics benefits
401(k) with company matching

Base Salary Range: $138,000 - $178,000 per year
Actual base salary will be determined by relevant professional experience, applicable skills, and internal equity.
COMPANY Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the companys ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoths deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.
Mammoth Biosciences requires that all employees be vaccinated against COVID as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.

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Mammoth Biosciences

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