Senior Downstream Process Development Scientist

Senior Downstream Process Development Scientist

• Full-time
• Technical Operations
• Cherrywood
• Last day to apply: 09/06/2026

APC was created out of a passion for science and research. In 2011, Dr. Mark Barrett and Prof. Brian Glennon of the UCD School of Chemical and Bioprocess Engineering in Dublin, Ireland, embarked on a mission to disrupt the pharma and biotech industries with a hyper-focused, accelerated approach to drug process development. Foregoing outside investment, APC has grown organically to become a global powerhouse in process development, partnering with companies large and small to bring medicines to market at unprecedented speed.

Our science and technology driven solutions have pioneered innovation in the sector, and we now partner with 8 of the top-10 pharma and 5 of the top-10 biotech firms in the world. From our world-class facility, our highly capable and qualified team delivers specialised chemical and process engineering solutions. Powered by novel technology and world-class scientific research, we help companies accelerate the development & launch of their medicines.

About the team

Department: Technical Operations

Reports to: DSP Functional Lead

Our Biologics team comprises of highly qualified, dynamic and welcoming colleagues. We support our clients by delivering world class bioprocess development to accelerate the delivery of quality, life-changing medicines to the patient across a wide range of therapeutic areas from oncolytic vaccines to rare genetic diseases.

Our team vision is to enhance the bioprocess development experience for our clients in a dynamic and cross-collaborative environment (APC Engineering, APC Biologics, APC Analytical, APC Quality & VLE GMP Manufacturing).

If you are looking to start your career in a dynamic, creative and patient focussed environment then APC is for you.

Technical and Operational Abilities

• Design, develop, and characterize purification processes across modalities
• Deep experience in core unit operations:
• Harvest, buffer prep, chromatography (AKTA; affinity, IEX, SEC, multimodal)
• Clarification & TFF (UF/DF)
• Viral clearance (filtration & inactivation)

Strong understanding of:

• cGMP compliance, regulatory expectations, and CMC development
• Optimize yield, purity, robustness, and cycle time through data-driven approaches
• Evaluate and implement new technologies (automation, high-throughput, single-use systems)
• Assess scalability, process economics, and manufacturability
• Provide operational support, troubleshooting, and deviation investigations
• Drive root cause analysis and implement CAPAs, change controls, and continuous improvement

Author, review, and own:

• Protocols, reports, SOPs, and technical documents
• CMC documentation for regulatory submissions
• Translate complex process challenges into actionable scientific solutions
• Troubleshoot unit operations and improve system performance
• Implement Lean, continuous improvement, and operational excellence initiatives
• Operate effectively in ambiguous environments without established procedures
• Strong technical writing and documentation skills
• High level of scientific rigor and problem-solving capability

Leadership & Project Delivery

• Act as project lead for multiple DSP programs; drive strategy and decision-making
• Manage cross-functional collaboration (Upstream, Analytical, QA, Manufacturing, Formulation)
• Deliver client-focused outcomes with clear communication and regular updates
• Mentor and coach junior scientists; support training and knowledge transfer
• Lead or contribute to publications, presentations, patents, and external engagements
• Strong internal and external stakeholder engagement (clients, partners)
• Present, defend, and influence technical decisions across matrix organizations
• Provide clear, concise technical updates and reports (written and verbal)
• Work effectively without direct authority; influence across disciplines
• Excellent interpersonal and communication skills
• Proven project management and multitasking ability

Experience & Qualifications

• PhD ( 5+ years), MSc ( 7+ years), or BSc ( 10+ years) in DSP

How to apply

Suitable candidates should submit a CV and a Cover Letter by close of business 08th June 2026

APC is committed to the principle of equal opportunity for all employees. All employment decisions at APC are based on business needs, job requirements and individual qualifications, without regard to gender, ethnicity, age, religious belief, disability, sexual orientation, gender identity and/or expression, marital status, or any other status protected by Irish law.

Similar vacancies arising in the coming 6 months may be filled from this group of applicants.